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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1566319
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sesn2
Name: sestrin 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:16189696480464CTDLipopolysaccharides results in increased expression of SESN2 mRNA

PMID:25637945
multiple interactionsISORGD:13468136480464CTDJUN protein promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of SESN2 protein], NFE2L2 protein promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of SESN2 protein], RELA protein inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of SESN2 protein]

PMID:25637945
multiple interactionsISORGD:16189696480464CTD[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of SESN2 mRNA, [Galactosamine co-treated with Lipopolysaccharides] results in increased expression of SESN2 protein, Cycloheximide inhibits the reaction [Lipopolysaccharides results in increased expression of SESN2 protein], Lipopolysaccharides inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of SESN2 protein], Lipopolysaccharides results in increased expression of and results in increased activity of SESN2 protein

PMID:25637945
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.