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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1566319
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sesn2
Name: sestrin 2
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:16189696480464CTDAcetaminophen affects the expression of SESN2 mRNA

PMID:17562736
decreases expressionISORGD:16189696480464CTDAcetaminophen results in decreased expression of SESN2 protein

PMID:28209544
increases expressionISORGD:13468136480464CTDAcetaminophen results in increased expression of SESN2 mRNA

PMID:21420995, PMID:22230336, PMID:29067470
multiple interactionsISORGD:16189696480464CTDSESN2 protein inhibits the reaction [Acetaminophen results in decreased expression of GPT protein], SESN2 protein inhibits the reaction [Acetaminophen results in increased cleavage of CASP3 protein], SESN2 protein inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA], SESN2 protein inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA], SESN2 protein inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA], SESN2 protein inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK1 protein], SESN2 protein inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK3 protein], SESN2 protein inhibits the reaction [Acetaminophen results in increased secretion of IL1B protein], SESN2 protein inhibits the reaction [Acetaminophen results in increased secretion of IL6 protein], SESN2 protein inhibits the reaction [Acetaminophen results in increased secretion of TNF protein]

PMID:28209544
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.