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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1566319
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sesn2
Name: sestrin 2
Acc ID: CHEBI:50161
Term: motexafin gadolinium
Definition: A metallotexaphyrin that has formula C52H72GdN5O14.
Chemical ID: MESH:C437683
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13468136480464CTDmotexafin gadolinium results in increased expression of SESN2 mRNA

PMID:16357179
multiple interactionsISORGD:13468136480464CTD[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA, [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA, nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]

PMID:16357179, PMID:20530418
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.