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GENE - TERM ANNOTATION REPORT

CRRD ID: 1566319
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Sesn2
Name: sestrin 2
Acc ID: GO:0031932
Term: TORC2 complex
Definition: A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.
Definition Source(s): GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
colocalizes_withIBAMGI:MGI:1922997, MGI:MGI:2651874, PANTHER:PTN00028000513792537GO_CentralPMID:21873635

 
colocalizes_withISORGD:16189691624291CRRD (MGI:MGI:5779633, PMID:25377878)

MGI:MGI:5779633, PMID:25377878
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