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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1583832
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pgd
Name: phosphogluconate dehydrogenase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:110876480464CTDTetrachlorodibenzodioxin affects the expression of PGD mRNA

PMID:21570461
increases expressionISORGD:110876480464CTDTetrachlorodibenzodioxin results in increased expression of PGD mRNA

PMID:15034205, PMID:26290441
multiple interactionsISORGD:110876480464CTD[Tetrachlorodibenzodioxin co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of PGD mRNA, [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PGD mRNA, [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of PGD mRNA

PMID:17942748, PMID:25975270, PMID:28433925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.