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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1593189
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gsta5
Name: glutathione S-transferase alpha 5
Acc ID: CHEBI:24814
Term: indole-3-methanol
Definition: An indolyl alcohol carrying a hydroxymethyl group at position 3. It is a constituent of the cruciferous vegetables and had anticancer activity.
Chemical ID: MESH:C016517
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDindole-3-carbinol affects the expression of GSTA5 mRNA

PMID:21396975
increases activityEXP 6480464CTDindole-3-carbinol results in increased activity of GSTA5 protein

PMID:9328168
increases expressionEXP 6480464CTDindole-3-carbinol results in increased expression of GSTA5, indole-3-carbinol results in increased expression of GSTA5 mRNA, indole-3-carbinol results in increased expression of GSTA5 protein

PMID:11446830, PMID:9794803, PMID:9806166
multiple interactionsEXP 6480464CTD[indole-3-carbinol co-treated with 1-cyano-2-hydroxy-3-butene] results in increased expression of GSTA5 mRNA, [indole-3-carbinol co-treated with 1-cyano-2-hydroxy-3-butene] results in increased expression of GSTA5 protein, [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTA5 mRNA, [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA, Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA]

PMID:11446830, PMID:22129741
increases expressionISORGD:16201186480464CTDindole-3-carbinol results in increased expression of GSTA1 protein

PMID:11309284
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.