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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1593189
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Gsta5
Name: glutathione S-transferase alpha 5
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of GSTA5 mRNA

PMID:19162173, PMID:28511854
increases expressionISORGD:16201186480464CTDperfluorooctanoic acid results in increased expression of GSTA1 mRNA, perfluorooctanoic acid results in increased expression of GSTA5 mRNA

PMID:18467677, PMID:20118188, PMID:20936131, PMID:23626681, PMID:30711707
multiple interactionsISORGD:16201186480464CTD[perfluorooctanoic acid co-treated with PPARA] results in decreased expression of GSTA1 mRNA, Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of GSTA1 mRNA], PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of GSTA1 mRNA], PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of GSTA5 mRNA]

PMID:18467677, PMID:20118188, PMID:20936131, PMID:23626681
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.