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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1615939
Species: Mus musculus
CRRD Object: Gene
Symbol: Thbs1
Name: thrombospondin 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[bis(4-hydroxyphenyl)sulfone co-treated with Tretinoin] results in decreased expression of THBS1 mRNA, [bisphenol A co-treated with Tretinoin] results in decreased expression of THBS1 mRNA, [bisphenol F co-treated with Tretinoin] results in decreased expression of THBS1 mRNA

PMID:30951980
decreases expressionISORGD:13459426480464CTDTretinoin results in decreased expression of THBS1 mRNA

PMID:15982314
increases expressionISORGD:13459426480464CTDTretinoin metabolite results in increased expression of THBS1 mRNA

PMID:15982314
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.