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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1615939
Species: Mus musculus
CRRD Object: Gene
Symbol: Thbs1
Name: thrombospondin 1
Acc ID: CHEBI:35696
Term: cobalt dichloride
Definition: A cobalt salt in which the cobalt metal is in the +2 oxidation state and the counter-anion is chloride. It is used as an indicator for water in desiccants.
Chemical ID: MESH:C018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13459426480464CTDcobaltous chloride results in decreased expression of THBS1 mRNA

PMID:19320972
decreases expressionISORGD:15884556480464CTDcobaltous chloride results in decreased expression of TSP1 mRNA

PMID:20524210
multiple interactionsISORGD:15884556480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in decreased expression of TSP1 mRNA], Acetylcysteine inhibits the reaction [cobaltous chloride results in decreased expression of TSP1 mRNA], U 0126 inhibits the reaction [cobaltous chloride results in decreased expression of TSP1 mRNA]

PMID:20524210
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.