Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1615939
Species: Mus musculus
CRRD Object: Gene
Symbol: Thbs1
Name: thrombospondin 1
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:13459426480464CTDFluorouracil affects the expression of THBS1 mRNA

PMID:15205334
affects response to substanceISORGD:13459426480464CTDTHBS1 protein affects the susceptibility to Fluorouracil

PMID:16217747
increases expressionISORGD:13459426480464CTDFluorouracil results in increased expression of THBS1 mRNA, Fluorouracil results in increased expression of THBS1 protein

PMID:18757417
multiple interactionsISORGD:13459426480464CTDEGR1 protein affects the reaction [Fluorouracil results in increased expression of THBS1 mRNA], EGR1 protein affects the reaction [Fluorouracil results in increased expression of THBS1 protein], Fluorouracil promotes the reaction [EGR1 protein binds to THBS1 promoter], SB 203580 inhibits the reaction [Fluorouracil results in increased expression of THBS1 mRNA]

PMID:18757417
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.