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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 1615939
Species: Mus musculus
CRRD Object: Gene
Symbol: Thbs1
Name: thrombospondin 1
Acc ID: CHEBI:75408
Term: sulindac sulfide
Definition: An aryl sulfide that is a metabolite of sulindac. A non-steroidal anti-inflammatory drug, which also has anticancer activity.
Chemical ID: MESH:C025462
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13459426480464CTDsulindac sulfide results in increased expression of THBS1 mRNA, sulindac sulfide results in increased expression of THBS1 protein

PMID:16227405, PMID:18261746
multiple interactionsISORGD:13459426480464CTD[sulindac sulfide results in increased activity of RHOA protein] which results in increased expression of THBS1 protein, [sulindac sulfide results in increased phosphorylation of MAPK1 protein] which results in increased expression of THBS1 protein, [sulindac sulfide results in increased phosphorylation of MAPK3 protein] which results in increased expression of THBS1 protein, EGR1 protein affects the reaction [sulindac sulfide results in increased expression of THBS1 mRNA], RHOA protein promotes the reaction [sulindac sulfide results in increased expression of THBS1 protein], U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 mRNA], U 0126 inhibits the reaction [sulindac sulfide results in increased expression of THBS1 protein]

PMID:16227405, PMID:18261746
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.