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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2012
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Acadm
Name: acyl-CoA dehydrogenase medium chain
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:100576480464CTDDiethylhexyl Phthalate results in increased expression of ACADM mRNA

PMID:19245819, PMID:19850644, PMID:20123618
increases expressionISORGD:7352596480464CTDDiethylhexyl Phthalate results in increased expression of ACADM mRNA

PMID:21354252
multiple interactionsISORGD:100576480464CTD[Tetrachlorodibenzodioxin co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in increased expression of ACADM mRNA, PPARA gene mutant form inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ACADM mRNA], PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of ACADM mRNA]

PMID:19850644, PMID:20123618, PMID:28433925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.