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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2012
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Acadm
Name: acyl-CoA dehydrogenase medium chain
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of ACADM mRNA

PMID:16221955
affects expressionISORGD:100576480464CTDperfluorooctanoic acid affects the expression of ACADM mRNA

PMID:19429403
increases expressionISORGD:100576480464CTDperfluorooctanoic acid results in increased expression of ACADM mRNA, perfluorooctanoic acid results in increased expression of ACADM protein

PMID:17681415, PMID:21499893, PMID:23626681
increases expressionISORGD:7352596480464CTDperfluorooctanoic acid results in increased expression of ACADM protein

PMID:26879310
multiple interactionsISORGD:100576480464CTD[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of ACADM mRNA

PMID:23626681
multiple interactionsISORGD:7352596480464CTD[PPARA co-treated with perfluorooctanoic acid] results in increased expression of ACADM mRNA, [PPARA co-treated with perfluorooctanoic acid] results in increased expression of ACADM protein

PMID:19751795
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.