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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2012
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Acadm
Name: acyl-CoA dehydrogenase medium chain
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDClofibrate results in increased expression of ACADM mRNA, Clofibrate results in increased expression of ACADM protein

PMID:11328961, PMID:12851107, PMID:15018640, PMID:16470657, PMID:17522070, PMID:18670166, PMID:9815135
increases expressionISORGD:100576480464CTDClofibrate results in increased expression of ACADM mRNA

PMID:17585979, PMID:19124612, PMID:23811191
multiple interactionsISORGD:100576480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of ACADM mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ACADM mRNA]

PMID:17585979
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.