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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2018
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Acly
Name: ATP citrate lyase
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDbisphenol A results in increased expression of ACLY mRNA

PMID:25181051, PMID:27178563
affects expressionISORGD:100656480464CTDbisphenol A affects the expression of ACLY mRNA

PMID:30903817
affects methylationISORGD:100646480464CTDbisphenol A affects the methylation of ACLY promoter

PMID:27334623
increases expressionISORGD:100646480464CTDbisphenol A results in increased expression of ACLY mRNA, bisphenol A results in increased expression of ACLY protein, bisphenol A results in increased expression of ACLY protein modified form

PMID:21932408
multiple interactionsISORGD:100646480464CTD[Tetrachlorodibenzodioxin co-treated with 2, 4, 5, 2', 4', 5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACLY mRNA

PMID:28433925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.