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CRRD ID: 2078
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Ak4
Name: adenylate kinase 4
Acc ID: GO:0071456
Term: cellular response to hypoxia
Definition: Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
Definition Source(s): GOC:mah
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:16065911624291CRRD (PMID:19130895), (PMID:23474458), (PMID:26980435), (PMID:30696468)

PMID:19130895, PMID:23474458, PMID:26980435, PMID:30696468

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.