GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2327
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cebpb
Name: CCAAT/enhancer binding protein beta
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of CEBPB mRNA

Lipopolysaccharides results in increased expression of CEBPB protein

PMID:11779202, PMID:21068073, PMID:21192080
increases activityISOCRRD:103266480464CTDLipopolysaccharides results in increased activity of CEBPB protein

PMID:14670622, PMID:15832817
increases expressionISOCRRD:103266480464CTDLipopolysaccharides results in increased expression of CEBPB protein

PMID:17316017
increases expressionISOCRRD:7362086480464CTDLipopolysaccharides results in increased expression of CEBPB mRNA

PMID:21911040
multiple interactionsISOCRRD:103266480464CTD3,3',4,5'-tetrahydroxystilbene promotes the reaction [Lipopolysaccharides results in increased expression of CEBPB protein]

[[PTPN6 protein results in increased phosphorylation of MAPK1 protein] which results in increased activity of CEBPB protein] promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

[[PTPN6 protein results in increased phosphorylation of MAPK3 protein] which results in increased activity of CEBPB protein] promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

arachidin-1 promotes the reaction [Lipopolysaccharides results in increased expression of CEBPB protein]

Genistein inhibits the reaction [Lipopolysaccharides results in increased activity of CEBPB protein]

genistin inhibits the reaction [Lipopolysaccharides results in increased activity of CEBPB protein]

resveratrol promotes the reaction [Lipopolysaccharides results in increased expression of CEBPB protein]

PMID:15832817, PMID:17316017, PMID:21422245
multiple interactionsISOCRRD:7362086480464CTDtrichostatin A inhibits the reaction [Lipopolysaccharides results in increased expression of CEBPB mRNA]

PMID:21911040
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.