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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2387
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cp
Name: ceruloplasmin
Acc ID: CHEBI:18248
Term: iron atom
Definition: An iron group element atom that has atomic number 26.
Chemical ID: MESH:D007501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDIron deficiency results in increased expression of CP protein

Iron deficiency results in increased expression of CP protein modified form

PMID:22457245, PMID:23814049
multiple interactionsEXP 6480464CTD[Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CP protein]

PMID:22534743
affects bindingISOCRRD:7367826480464CTDCP protein binds to [TF protein binds to Iron]

PMID:21049900
decreases exportISOCRRD:7367826480464CTDCP gene mutant form results in decreased export of Iron

PMID:20801540
increases abundanceISOCRRD:103846480464CTDCP gene mutant form results in increased abundance of Iron

PMID:16988052
increases activityISOCRRD:7367826480464CTDIron deficiency results in increased activity of CP promoter

PMID:10777486
increases oxidationISOCRRD:7367826480464CTDCP protein results in increased oxidation of Iron

PMID:12572680, PMID:20655381
multiple interactionsISOCRRD:103846480464CTD[CP gene mutant form results in increased abundance of Iron] which results in decreased expression of TFRC mRNA

[CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTH1 mRNA

[CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTL mRNA

[CP gene mutant form results in increased abundance of Iron] which results in increased expression of SLC11A1 mRNA

Iron inhibits the reaction [Diethylnitrosamine results in increased expression of CP protein]

PMID:16988052, PMID:19061943
multiple interactionsISOCRRD:7367826480464CTD[CP protein results in increased oxidation of Iron] which results in increased stability of SLC40A1 protein

ARNT protein affects the reaction [Iron deficiency results in increased activity of CP promoter]

PMID:10777486, PMID:20655381
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.