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CRRD ID: 2432
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cst3
Name: cystatin C
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7369146480464CTDCisplatin results in increased expression of CST3, Cisplatin results in increased expression of CST3 mRNA

PMID:22525860, PMID:27392435, PMID:27594783
multiple interactionsISORGD:7369146480464CTD[Cisplatin co-treated with jinfukang] results in increased expression of CST3 mRNA, Cimetidine inhibits the reaction [Cisplatin results in increased expression of CST3], SLC22A2 gene polymorphism inhibits the reaction [Cisplatin results in increased expression of CST3]

PMID:22525860, PMID:27392435
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.