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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2443
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cth
Name: cystathionine gamma-lyase
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7320846480464CTDAflatoxin B1 affects the expression of CTH protein

PMID:20106945
decreases expressionISORGD:7320846480464CTDAflatoxin B1 results in decreased expression of CTH mRNA

PMID:21632981, PMID:21641981, PMID:22100608, PMID:27153756
decreases expressionISORGD:7320856480464CTDAflatoxin B1 results in decreased expression of CTH mRNA

PMID:19770486
decreases methylationISORGD:7320846480464CTDAflatoxin B1 results in decreased methylation of CTH gene

PMID:27153756
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.