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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2443
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cth
Name: cystathionine gamma-lyase
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISORGD:7320856480464CTDAcetaminophen affects the expression of CTH mRNA

PMID:17562736
decreases expressionISORGD:7320846480464CTDAcetaminophen results in decreased expression of CTH mRNA

PMID:26690555
decreases expressionISORGD:7320856480464CTDAcetaminophen results in decreased expression of CTH mRNA

PMID:29246445
increases activityISORGD:7320856480464CTDAcetaminophen results in increased activity of CTH protein

PMID:25499718
increases expressionISORGD:7320846480464CTDAcetaminophen results in increased expression of CTH mRNA

PMID:21420995, PMID:29067470
increases response to substanceISORGD:7320856480464CTDCTH gene mutant form results in increased susceptibility to Acetaminophen

PMID:25499718
multiple interactionsISORGD:7320856480464CTD[CTH gene mutant form results in increased susceptibility to Acetaminophen] which affects the expression of ARIH2 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which affects the expression of EEF2 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of ACSL1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of ADK protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of ALDH1L1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of CAR3 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of DHDH protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of EIF5A protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of FBP1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GSTM1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GSTP1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GSTT1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GSTZ1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of HAAO protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of HPD protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of INMT protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of KRT8 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of LDHA protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of MAT1A protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of PAH protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of PGAM1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of PPA1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of PRDX6 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of RASL12 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of RGN protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of SOD1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of SORD protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of ACLY protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of ALB protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of ALDH4A1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of APOA1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of C3 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of CAT protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of CES1C protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of CPS1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of ENO1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of FGB protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of GPT protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of GSN protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of HMGCS2 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of HSPA9 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of PCX protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of PRDX1 protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of SDHA protein, [CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in increased expression of TRF protein, PANX1 gene mutant form inhibits the reaction [Acetaminophen results in decreased expression of CTH mRNA]

PMID:25499718, PMID:29246445
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.