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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2456
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp17a1
Name: cytochrome P450, family 17, subfamily a, polypeptide 1
Acc ID: CHEBI:35497
Term: androgen antagonist
Definition: A compound which inhibits or antagonises the biosynthesis or actions of androgens.
Chemical ID: MESH:D000726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of CYP17A1 mRNA, [Pesticides co-treated with Phthalic Acids co-treated with Androgen Antagonists] results in decreased expression of CYP17A1 mRNA

PMID:25607892, PMID:29945228
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.