Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


CRRD ID: 2459
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:3647
Term: chlorpromazine
Definition: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Chemical ID: MESH:D002746
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDChlorpromazine affects the expression of CYP1A2 mRNA

increases expressionEXP 6480464CTDChlorpromazine results in increased expression of CYP1A2 mRNA

decreases methylationISORGD:7357116480464CTDCYP1A2 protein results in decreased methylation of Chlorpromazine

decreases response to substanceISORGD:7357116480464CTDCYP1A2 protein results in decreased susceptibility to Chlorpromazine

increases oxidationISORGD:7357116480464CTDCYP1A2 protein results in increased oxidation of Chlorpromazine

multiple interactionsISORGD:7357116480464CTD[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA, [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine, Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein], CYP1A2 protein results in increased metabolism of and results in increased activity of Chlorpromazine

PMID:18493746, PMID:19482014, PMID:23397584, PMID:27344345
Go Back to source page   Continue to Ontology report


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.