Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2459
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:3647
Term: chlorpromazine
Definition: A substituted phenothiazine in which the ring nitrogen at position 10 is attached to C-3 of an N,N-dimethylpropanamine moiety.
Chemical ID: MESH:D002746
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDChlorpromazine affects the expression of CYP1A2 mRNA

PMID:18246545
increases expressionEXP 6480464CTDChlorpromazine results in increased expression of CYP1A2 mRNA

PMID:25596134
decreases methylationISORGD:7357116480464CTDCYP1A2 protein results in decreased methylation of Chlorpromazine

PMID:20615392
decreases response to substanceISORGD:7357116480464CTDCYP1A2 protein results in decreased susceptibility to Chlorpromazine

PMID:26477383
increases oxidationISORGD:7357116480464CTDCYP1A2 protein results in increased oxidation of Chlorpromazine

PMID:20615392
multiple interactionsISORGD:7357116480464CTD[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA, [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine, Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein], CYP1A2 protein results in increased metabolism of and results in increased activity of Chlorpromazine

PMID:18493746, PMID:19482014, PMID:23397584, PMID:27344345
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.