GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2459
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:7550
Term: Nicardipine
Definition: A dihydropyridine that has formula C26H29N3O6.
Chemical ID: MESH:D009529
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISOCRRD:7357116480464CTDNicardipine results in decreased activity of CYP1A2 protein

PMID:15863898
increases expressionISOCRRD:7357116480464CTDNicardipine results in increased expression of CYP1A2 mRNA

PMID:20067464
multiple interactionsISOCRRD:7357116480464CTDMethylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A2 mRNA]

Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA]

PMID:20067464
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.