GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2459
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:77260
Term: 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole
Definition: A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.
Chemical ID: MESH:D009853
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDOmeprazole results in increased expression of CYP1A2 mRNA

Omeprazole results in increased expression of CYP1A2 protein

PMID:19118567, PMID:25626140, PMID:9152597
multiple interactionsEXP 6480464CTD[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA

PMID:22687989
decreases activityISOCRRD:104386480464CTDOmeprazole results in decreased activity of CYP1A2 protein

PMID:18420780
decreases activityISOCRRD:7357116480464CTDOmeprazole results in decreased activity of CYP1A2 protein

PMID:16035375
increases activityISOCRRD:7357116480464CTDOmeprazole results in increased activity of CYP1A2 promoter

Omeprazole results in increased activity of CYP1A2 protein

PMID:18502397, PMID:19118567, PMID:19230594, PMID:23274770
increases expressionISOCRRD:7357116480464CTDOmeprazole results in increased expression of CYP1A2 mRNA

Omeprazole results in increased expression of CYP1A2 protein

PMID:12040753, PMID:12623754, PMID:12841937, PMID:15681896, PMID:15802389, PMID:17954527, PMID:18332078, PMID:19118567, PMID:19230594, PMID:20171196, PMID:21784029, PMID:21924250, PMID:22524704, PMID:23274770, PMID:23850985, PMID:24752503, PMID:26204831, PMID:27794450, PMID:9744552
multiple interactionsISOCRRD:7357116480464CTD[Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin

AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]

Omeprazole results in increased expression of and results in increased activity of CYP1A2 protein

PMID:15802389, PMID:20171196, PMID:22524704
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.