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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2460
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:34569
Term: Benzo[k]fluoranthene
Definition: A naphthalene that has formula C20H12.
Chemical ID: MESH:C022921
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:104396480464CTDbenzo(k)fluoranthene results in increased expression of CYP1B1 mRNA

PMID:26377693
increases expressionISOCRRD:7367656480464CTDbenzo(k)fluoranthene results in increased expression of CYP1B1 mRNA

PMID:15566942, PMID:17253728, PMID:19358281, PMID:24472612, PMID:27196671
increases hydroxylationISOCRRD:7367656480464CTDCYP1B1 protein results in increased hydroxylation of benzo(k)fluoranthene

PMID:17919675
multiple interactionsISOCRRD:7367656480464CTD[phenanthrene co-treated with pyrene co-treated with Benzo(a)pyrene co-treated with benzo(k)fluoranthene co-treated with dibenzo(a,l)pyrene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA

benzo(k)fluoranthene affects the reaction [CYP1B1 protein results in increased hydroxylation of Estradiol]

PMID:15566942, PMID:17919675
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.