GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2460
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:48347
Term: triclocarban
Definition: A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.
Chemical ID: MESH:C009540
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:104396480464CTDtriclocarban results in increased expression of CYP1B1 mRNA

PMID:22761658
increases expressionISOCRRD:7367656480464CTDtriclocarban results in increased expression of CYP1B1 mRNA

PMID:22761658
multiple interactionsISOCRRD:7367656480464CTDESR1 protein affects the reaction [triclocarban results in increased expression of CYP1B1 mRNA]

triclocarban promotes the reaction [bisphenol A results in increased expression of CYP1B1 mRNA]

triclocarban promotes the reaction [Genistein results in increased expression of CYP1B1 mRNA]

PMID:22761658, PMID:23524099
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.