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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2460
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:5885
Term: imperatorin
Definition: A member of the class of psoralens that is psoralen substituted by a prenyloxy group at position 8. Isolated from Angelica dahurica and Angelica koreana, it acts as a acetylcholinesterase inhibitor.
Chemical ID: MESH:C031534
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISOCRRD:7367656480464CTDimperatorin results in decreased activity of CYP1B1 protein

imperatorin results in decreased activity of CYP1B1 protein polymorphism

PMID:15861043
multiple interactionsISOCRRD:7367656480464CTDimperatorin inhibits the reaction [CYP1B1 protein results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol]

PMID:15861043
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.