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GENE - TERM ANNOTATION REPORT

CRRD ID: 2466
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Cyp2b1
Name: cytochrome P450, family 2, subfamily b, polypeptide 1
Acc ID: DOID:1793
Term: pancreatic cancer
Definition: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Definition Source(s): MESH:D010190, http://en.wikipedia.org/wiki/Pancreatic
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 EXP 11554173CTDCTD Direct Evidence: therapeutic

PMID:10026857, PMID:10326030, PMID:10415878, PMID:11332152, PMID:11377651, PMID:12042985, PMID:12649565, PMID:12698877
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.