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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2835
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:7374686480464CTDProgesterone results in decreased activity of HSD11B2 protein

PMID:18032417
decreases expressionISORGD:7374686480464CTDProgesterone results in decreased expression of HSD11B2 mRNA, Progesterone results in decreased expression of HSD11B2 protein

PMID:18032417, PMID:18070364, PMID:21540246
increases expressionISORGD:7374686480464CTDProgesterone results in increased expression of HSD11B2 mRNA

PMID:15857753
multiple interactionsISORGD:7374686480464CTD[Estradiol co-treated with Progesterone] results in increased expression of HSD11B2 mRNA, benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Progesterone results in increased expression of HSD11B2 mRNA], Masoprocol inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein], Mifepristone inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein], Mifepristone inhibits the reaction [Progesterone results in decreased expression of HSD11B2 mRNA], Mifepristone inhibits the reaction [Progesterone results in decreased expression of HSD11B2 protein]

PMID:15857753, PMID:18032417, PMID:20660070
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.