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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2835
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDNicotine results in decreased expression of HSD11B2 mRNA, Nicotine results in decreased expression of HSD11B2 protein

PMID:22265867
increases expressionEXP 6480464CTDNicotine results in increased expression of HSD11B2 mRNA, Nicotine results in increased expression of HSD11B2 protein

PMID:29486207
increases expressionISORGD:7374686480464CTDNicotine results in increased expression of HSD11B2 mRNA, Nicotine results in increased expression of HSD11B2 protein

PMID:29486207
multiple interactionsISORGD:7374686480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3, 4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA], 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3, 4-difluoro-5-bromobenzamide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein], EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 mRNA], EGR1 protein promotes the reaction [Nicotine results in decreased expression of HSD11B2 protein], Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein]

PMID:29486207
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.