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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2835
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:79736
Term: ziram
Definition: A dithiocarbamate salt that is the zinc salt of dimethyldithiocarbamic acid. It is a broad-spectrum fungicide and bird and animal repellent that is also used to accelerate the vulcanisation of rubber.
Chemical ID: MESH:D015039
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityEXP 6480464CTDZiram results in decreased activity of HSD11B2 protein

PMID:26859423
multiple interactionsEXP 6480464CTDDithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein], Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone], Ziram inhibits the reaction [HSD11B2 protein results in increased oxidation of Corticosterone], Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD]

PMID:26859423
decreases activityISORGD:7374686480464CTDZiram results in decreased activity of HSD11B2 protein

PMID:26859423
multiple interactionsISORGD:7374686480464CTDDithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein], Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone], Ziram inhibits the reaction [HSD11B2 protein results in increased oxidation of Hydrocortisone], Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD]

PMID:26859423
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.