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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2835
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Hsd11b2
Name: hydroxysteroid 11-beta dehydrogenase 2
Acc ID: CHEBI:9495
Term: thiram
Definition: An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.
Chemical ID: MESH:D013893
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases activityISORGD:7374686480464CTDThiram results in decreased activity of HSD11B2 protein

PMID:12901862, PMID:16857225, PMID:22796344
multiple interactionsISORGD:7374686480464CTDDithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein], Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein], Thiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Dexamethasone]

PMID:12901862, PMID:16857225, PMID:22796344
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.