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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2860
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Id3
Name: inhibitor of DNA binding 3, HLH protein
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of ID3 mRNA

PMID:22298810
increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of ID3 mRNA

PMID:21496263, PMID:23238561
affects expressionISORGD:15537776480464CTDTetrachlorodibenzodioxin affects the expression of ID3 mRNA

PMID:16611356, PMID:21570461, PMID:26377647
decreases expressionISORGD:15537776480464CTDTetrachlorodibenzodioxin results in decreased expression of ID3 mRNA

PMID:19684285, PMID:19933214
decreases expressionISORGD:7340696480464CTDTetrachlorodibenzodioxin results in decreased expression of ID3 mRNA

PMID:17257637, PMID:19684285, PMID:29704546
increases expressionISORGD:15537776480464CTDTetrachlorodibenzodioxin results in increased expression of ID3 mRNA

PMID:15591033, PMID:17942748, PMID:19684285, PMID:21496263, PMID:23238561
increases expressionISORGD:7340696480464CTDTetrachlorodibenzodioxin results in increased expression of ID3 mRNA

PMID:19684285, PMID:21496263
multiple interactionsISORGD:15537776480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of ID3 mRNA

PMID:25975270
multiple interactionsISORGD:7340696480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ID3 mRNA]

PMID:29704546
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.