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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2860
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Id3
Name: inhibitor of DNA binding 3, HLH protein
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of ID3 mRNA

PMID:12655037, PMID:15576828, PMID:15834898, PMID:17557909
multiple interactionsISORGD:15537776480464CTDEthinyl Estradiol inhibits the reaction [IL1B protein results in increased expression of ID3 mRNA]

PMID:12072388
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.