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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2862
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Idh1
Name: isocitrate dehydrogenase (NADP(+)) 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects response to substanceISORGD:7371456480464CTDIDH1 protein affects the susceptibility to Tretinoin

PMID:26951332
increases expressionISORGD:7371456480464CTDTretinoin results in increased expression of IDH1 mRNA

PMID:23830798
multiple interactionsISORGD:7371456480464CTD[IDH1 protein affects the susceptibility to Tretinoin] which affects the cleavage of CASP3 protein, [IDH1 protein affects the susceptibility to Tretinoin] which affects the cleavage of PARP1 protein, [IDH1 protein affects the susceptibility to Tretinoin] which affects the expression of BCL2 protein, [IDH1 protein affects the susceptibility to Tretinoin] which affects the expression of ITGAM protein, IDH1 protein affects the reaction [Tretinoin results in increased expression of ITGAM protein]

PMID:26951332
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.