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GENE - TERM ANNOTATION REPORT

CRRD ID: 2862
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Idh1
Name: isocitrate dehydrogenase (NADP(+)) 1
Acc ID: DOID:0050902
Term: medulloblastoma
Definition: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
Definition Source(s): MESH:D008527, http://en.wikipedia.org/wiki/Medulloblastoma, http://www.cancer.gov/dictionary?CdrID=45780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Medulloblastoma

PMID:18772396, PMID:19657110, PMID:19798509, PMID:19818334, PMID:21446021, PMID:22160010, PMID:22397365, PMID:22417203, PMID:22898539, PMID:23558169, PMID:24606448, PMID:25043048, PMID:25157968, PMID:26619011
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Medulloblastoma

PMID:19657110, PMID:20946881, PMID:22160010, PMID:22397365, PMID:22417203, PMID:22898539, PMID:25157968, PMID:26619011
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Medulloblastoma

PMID:19657110, PMID:21352804, PMID:22160010, PMID:22417203, PMID:22898539, PMID:25157968, PMID:26619011
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Medulloblastoma

PMID:20946881, PMID:22160010, PMID:22397365, PMID:22417203, PMID:22898539, PMID:26619011
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Medulloblastoma

PMID:22160010, PMID:22397365, PMID:22417203, PMID:22898539, PMID:26619011
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.