Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - TERM ANNOTATION REPORT

CRRD ID: 2862
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Idh1
Name: isocitrate dehydrogenase (NADP(+)) 1
Acc ID: DOID:9119
Term: acute myeloid leukemia
Definition: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Definition Source(s): MESH:D015470, http://cancergenome.nih.gov/cancersselected/acutemyeloidleukemia, http://en.wikipedia.org/wiki/Acute_myeloid_leukemia, http://www.cancer.gov/dictionary?cdrid=44363, https://www.cancer.org/cancer/acute-myeloid-leukemia/detection-diagnosis-staging/how-classified.html
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Acute myelogenous leukemia

PMID:18772396, PMID:19657110, PMID:19798509, PMID:19818334, PMID:21446021, PMID:22160010, PMID:22397365, PMID:22417203, PMID:22898539, PMID:23558169, PMID:24606448, PMID:25043048, PMID:25157968, PMID:25741868, PMID:26619011
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Acute myeloid leukemia

PMID:22160010, PMID:22417203, PMID:22898539
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Leukemia, acute myelogenous

PMID:19657110, PMID:20946881, PMID:22160010, PMID:22397365, PMID:22417203, PMID:22898539, PMID:25157968, PMID:26619011
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Leukemia, acute myelogenous

PMID:19657110, PMID:21352804, PMID:22160010, PMID:22417203, PMID:22898539, PMID:25157968, PMID:26619011
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Leukemia, acute myelogenous

PMID:20946881, PMID:22160010, PMID:22397365, PMID:22417203, PMID:22898539, PMID:26619011
 ISORGD:7371458554872ClinVarClinVar Annotator: match by term: Leukemia, acute myelogenous

PMID:22160010, PMID:22397365, PMID:22417203, PMID:22898539, PMID:26619011
 ISORGD:73714511554173CTDCTD Direct Evidence: marker/mechanism

PMID:25324972, PMID:27992414
disease_progressionISORGD:73714511522718CRRDDNA:mutation:cds:p.R132(human)

 
disease_progressionISORGD:73714511522721CRRDDNA:SNP::105C>T (rs11554137)(human)

 
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.