GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2874
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Igfbp3
Name: insulin-like growth factor binding protein 3
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDexamethasone results in increased expression of IGFBP3 mRNA

PMID:20032058
multiple interactionsEXP 6480464CTDTestosterone inhibits the reaction [Dexamethasone results in increased expression of IGFBP3 mRNA]

PMID:20032058
decreases expressionISOCRRD:7360426480464CTDDexamethasone results in decreased expression of IGFBP3 mRNA

PMID:25047013
multiple interactionsISOCRRD:107746480464CTD[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA

[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA]

Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of IGFBP3 mRNA]

PMID:16054899
multiple interactionsISOCRRD:7360426480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of IGFBP3 mRNA

PMID:28628672
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.