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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 2894
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Il1rl1
Name: interleukin 1 receptor-like 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pleasant odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDOzone results in increased expression of IL1RL1 mRNA

PMID:16716893
multiple interactionsEXP 6480464CTD[Ozone co-treated with Chlorine] results in decreased expression of IL1RL1 mRNA

PMID:18636392
multiple interactionsISORGD:7361596480464CTDIL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CCL4 protein], IL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of CXCL1 protein], IL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL13 protein], IL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL5 protein], IL1RL1 protein affects the reaction [[LEP gene mutant form results in increased susceptibility to Ozone] which results in increased expression of IL6 protein]

PMID:27472835
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.