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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3001
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of LEPR mRNA

PMID:25181051
multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of LEPR mRNA

PMID:26496021
increases expressionISORGD:7358326480464CTDbisphenol A results in increased expression of LEPR mRNA, bisphenol A results in increased expression of LEPR protein

PMID:22343039
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.