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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3074
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Me1
Name: malic enzyme 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with 1, 2, 5, 6-dibenzanthracene] affects the expression of ME1 mRNA, [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of ME1 mRNA, [Benzo(a)pyrene co-treated with dibenzo(a, l)pyrene] affects the expression of ME1 mRNA, [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of ME1 mRNA

PMID:18711122
increases expressionISORGD:108906480464CTDBenzo(a)pyrene results in increased expression of ME1 mRNA

PMID:20127859
increases expressionISORGD:7361336480464CTDBenzo(a)pyrene results in increased expression of ME1 mRNA

PMID:22316170, PMID:31255691
multiple interactionsISORGD:108906480464CTDAHR protein affects the reaction [Benzo(a)pyrene affects the expression of ME1 mRNA]

PMID:22228805
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.