RGD Gene Chemical Interaction Report - Chinchilla Research Resource Database

GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID:	3074
Species:	Rattus norvegicus
CRRD Object:	Gene
Symbol:	Me1
Name:	malic enzyme 1

Acc ID:	CHEBI:29865
Term:	benzo[a]pyrene
Definition:	An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID:	MESH:D001564

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[Benzo(a)pyrene co-treated with 1, 2, 5, 6-dibenzanthracene] affects the expression of ME1 mRNA, [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of ME1 mRNA, [Benzo(a)pyrene co-treated with dibenzo(a, l)pyrene] affects the expression of ME1 mRNA, [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of ME1 mRNA	PMID:18711122
increases expression	ISO	RGD:10890	6480464	CTD	Benzo(a)pyrene results in increased expression of ME1 mRNA	PMID:20127859
increases expression	ISO	RGD:736133	6480464	CTD	Benzo(a)pyrene results in increased expression of ME1 mRNA	PMID:22316170, PMID:31255691
multiple interactions	ISO	RGD:10890	6480464	CTD	AHR protein affects the reaction [Benzo(a)pyrene affects the expression of ME1 mRNA]	PMID:22228805

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

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