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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3074
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Me1
Name: malic enzyme 1
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases response to substanceISORGD:7361336480464CTDME1 protein results in decreased susceptibility to Arsenic Trioxide

PMID:20707922
increases expressionISORGD:7361336480464CTDArsenic Trioxide results in increased expression of ME1 mRNA

PMID:15725085, PMID:19417148, PMID:20458559, PMID:25258189, PMID:26705709
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.