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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3074
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Me1
Name: malic enzyme 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of ME1 mRNA

PMID:19638242
multiple interactionsEXP 6480464CTD[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of ME1 mRNA, [Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA, [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ME1 mRNA, [indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA, [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA, [oxfendazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA, Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA], isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA], Melatonin inhibits the reaction [[Diethylnitrosamine co-treated with oxfendazole] results in increased expression of ME1 mRNA]

PMID:18754104, PMID:20033131, PMID:20360939, PMID:22129741, PMID:22687989
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.