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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3122
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Muc1
Name: mucin 1, cell surface associated
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in increased expression of MUC1 mRNA

PMID:26496021
affects expressionISOCRRD:109276480464CTDEstradiol affects the expression of MUC1 mRNA

PMID:15598610
increases expressionISOCRRD:109276480464CTDEstradiol results in increased expression of MUC1 mRNA

Estradiol results in increased expression of MUC1 protein

PMID:15289156, PMID:30061528
multiple interactionsISOCRRD:109276480464CTDFulvestrant inhibits the reaction [Estradiol results in increased expression of MUC1 mRNA]

PMID:30061528
multiple interactionsISOCRRD:7372526480464CTD[Estradiol binds to ESR2 protein] which results in increased expression of MUC1 mRNA

[Estradiol co-treated with TGFB1 protein] results in decreased expression of MUC1 mRNA

PMID:20404318, PMID:30165855
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.