GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3122
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Muc1
Name: mucin 1, cell surface associated
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISOCRRD:7372526480464CTDDexamethasone results in increased expression of MUC1 protein

PMID:9949172
multiple interactionsISOCRRD:7372526480464CTD[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of MUC1 mRNA

Mifepristone inhibits the reaction [Dexamethasone results in increased expression of MUC1 protein]

PMID:16997883, PMID:9949172
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.