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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3202
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Acc ID: CHEBI:34911
Term: permethrin
Definition: A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups.
Chemical ID: MESH:D026023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDPermethrin affects the expression of NR4A2 mRNA

PMID:23566817
decreases expressionEXP 6480464CTDPermethrin results in decreased expression of NR4A2, Permethrin results in decreased expression of NR4A2 mRNA, Permethrin results in decreased expression of NR4A2 protein

PMID:22056222, PMID:23174539, PMID:25048945
increases expressionEXP 6480464CTDPermethrin results in increased expression of NR4A2 mRNA, Permethrin results in increased expression of NR4A2 protein

PMID:23566817, PMID:28943456, PMID:29051472
multiple interactionsEXP 6480464CTDGlutathione inhibits the reaction [Permethrin results in increased expression of NR4A2 mRNA], Tocotrienols inhibits the reaction [Permethrin results in increased expression of NR4A2 mRNA]

PMID:28943456
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