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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3202
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Acc ID: CHEBI:48607
Term: lithium chloride
Definition: A metal chloride salt with a Li(+) counterion.
Chemical ID: MESH:D018021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDLithium Chloride results in increased expression of NR4A2 mRNA, Lithium Chloride results in increased expression of NR4A2 protein

PMID:27045591
multiple interactionsEXP 6480464CTDCTNNB1 protein affects the reaction [Lithium Chloride results in increased expression of NR4A2 mRNA], Lithium Chloride inhibits the reaction [Rotenone results in decreased expression of NR4A2 protein], Lithium Chloride promotes the reaction [CTNNB1 protein binds to NR4A2 promoter], Lithium Chloride promotes the reaction [CTNNB1 protein binds to NR4A2 protein]

PMID:27045591
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.