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GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3322
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Phb
Name: prohibitin
Acc ID: CHEBI:3090
Term: bicalutamide
Definition: A racemate comprising of equal amounts of (R)-bicalutamide and (S)-bicalutamide. It is an oral non-steroidal antiandrogen used in the treatment of prostate cancer and hirsutism.
Chemical ID: MESH:C053541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsISORGD:7369486480464CTD[Dihydrotestosterone co-treated with bicalutamide] promotes the reaction [AR protein binds to PHB protein], AR protein promotes the reaction [bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter]], bicalutamide promotes the reaction [PHB protein binds to KLK3 promoter], PHB protein promotes the reaction [bicalutamide inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]], PHB protein promotes the reaction [bicalutamide promotes the reaction [SMARCA4 protein binds to KLK3 promoter]]

PMID:18487222
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.