GENE - CHEMICAL INTERACTIONS REPORT

CRRD ID: 3330
Species: Rattus norvegicus
CRRD Object: Gene
Symbol: Pim1
Name: Pim-1 proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionISOCRRD:111046480464CTDTetrachlorodibenzodioxin affects the expression of PIM1 mRNA

PMID:21570461
increases expressionISOCRRD:7375166480464CTDTetrachlorodibenzodioxin results in increased expression of PIM1 mRNA

PMID:20106945, PMID:21632981, PMID:26238291
multiple interactionsISOCRRD:111046480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PIM1 promoter]

PMID:19654925
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.